Effect of Beta-Endorphin on Pain Threshold Hypophysectomized Rats
نویسندگان
چکیده
Beta-endorphin (fS-EP) is a 31 amino acid polypeptide secreted by the pituitary, brain, and various other tissues. it has potent opiate-like activity, can produce analgesia, and may play a physiological role in adapting the immune system to stress by affecting Iymphocyte and complement binding activity. To investigate the effect of fS-EPon pain threshold, we analyzed cerebrospinal fluid (CSF) and plasma concentrations of fS-EPin 12 intact and 12 hypophysectomized (HYP) rats. Plasma and CSF samples were obtained from both intad and HYP rats 24 hours postsurgery. Pain threshold values were then assessed using the tail-flick test. Results show ed a decrease in the plasma concentration of fS-EP(p < 0.001), but no significant difference in the level in CSP. Key Worrls: Beta-endorphin, hypophysectomy, pain threshold, tail-flick test
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